Protein Misfolding in Degenerative Diseases
This framework is based on a cooperation aggreement with the Charité and is supported by the Center of Scientific Computation (CSS : FU Berlin). The project deals with an exploration of various diseases which have in common a perturbation of protein folding. As a consequence of this misfolding an aggregation of proteins with a fibrillar structure can show up. Or alternatively some diseases can appear due to a complete absence of functionally important proteins. Two representative diseases (Alzheimers' disease and LGMD 2B) are analyzed. Computational simulation-techniques with different models and methods are used to gain a deeper understanding of the molecular processes of these diseases. This includes classical molecular dynamics simulations for systems found in non-equilibrium as well as homology modeling in order to determine the relevant protein structure.
Further information is available in the detailed project description.
Simone Spuler (Charite)
06/2011 - 06/2013
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