CSS

Protein Misfolding in Degenerative Diseases

Description

This framework is based on a cooperation aggreement with the Charité and is supported by the Center of Scientific Computation (CSS : FU Berlin). The project deals with an exploration of various diseases which have in common a perturbation of protein folding. As a consequence of this misfolding an aggregation of proteins with a fibrillar structure can show up. Or alternatively some diseases can appear due to a complete absence of functionally important proteins. Two representative diseases (Alzheimers' disease and LGMD 2B) are analyzed. Computational simulation-techniques with different models and methods are used to gain a deeper understanding of the molecular processes of these diseases. This includes classical molecular dynamics simulations for systems found in non-equilibrium as well as homology modeling in order to determine the relevant protein structure.  

Further information is available in the detailed project description.

Members 

Marcus Weber 
Konstantin Fackeldey 
Karsten Andrae

Responsible 

Marcus Weber 
Konstantin Fackeldey

Partners

Simone Spuler (Charite)

Funding

CSS (FU-Berlin) 

Duration

06/2011 - 06/2013