Prof. S. Waters (University of Oxford, GB)
Monday, April 23, 2018 - 14:00
Weierstraß-Institut
Mohrenstr. 39, 10117 Berlin, Erhard-Schmidt-Hörsaal, Erdgeschoss
Seminar Quantitative Biomedizin
Tissue engineers aim to grow tissues in vitro to replace those in the body that have been damaged through age, trauma or disease. A common approach is to seed cells within a scaffold which is then cultured in a bioreactor. The key challenge it to provide the appropriate mechanical and biochemical cellular environment that promotes tissue growth in vitro. Fluid flows have a key role to play in addressing this challenge, as they can provide mechanical cues to cells (e.g. via fluid shear and pressure), and enhance the delivery of nutrients and growth factors (via advection). In this talk, I will explore how mechanistic mathematical models, in combination with state-of-the art experimental studies, can provide quantitative insights into the interplay between the fluid flows and the resulting tissue growth. Quantitative understanding of this interplay offers the exciting potential to manipulate the experimental design (e.g. scaffold porosity, bioreactor operating conditions) to establish defined mechanical cues that enhance the generation of complex 3D tissues in vitro.
submitted by hohn (ina.hohn@wias-berlin.de, 030 20372591)