Math-Powered Drug Design
This project aims at the creation of a MATH+ success story around the mathematics of drug design. It proposes a new drug design strategy for G-protein coupled receptors by distinguishing between the effects of drugs in healthy and pathological environment. It extends previous projects by (I) coupling the molecular timescales of receptor activation with the associated cellular processes and the adverse side effects induced by them, and by (II) generalizing the new strategy beyond opioid receptors and pain relief towards the treatment of e.g. blood pressure, heart failure, or respiratory failure (e.g. Covid-19).
Publikationen
2022
2022 |
|||
Alberto Montefusco, Christof Schütte, Stefanie Winkelmann | A route to the hydrodynamic limit of a reaction-diffusion master equation using gradient structures | 2022 (under review) |
BibTeX
|
Horst-Holger Boltz, Alexei Sirbu, Nina Stelzer, Primal de Lanerolle, Stefanie Winkelmann, Paolo Annibale | The Impact of Membrane Protein Diffusion on GPCR Signaling | Cells, 11(10), p. 1660, 2022 (in press) |
BibTeX
DOI |