Mathematical Systems Biology
Systems biology is a lively interdisciplinary research field that has received considerable attention in recent years. While traditional molecular biology studies the various components of a biological system (genes, RNAs, proteins,...) in isolation, systems biology aims to understand how these components interact in order to perform higher-level functions. Mathematical modeling then plays a major role not only in capturing and analyzing complex networks governing biological processes, but also as a way to verify hypotheses based on observational evidence and in designing efficient experiments to further the understanding of the system. The goal of this project is to pool our knowledge on discrete, deterministic and stochastic modeling of biological systems to pave the way towards efficient hybrid models (discrete/continuous, deterministic/stochastic) for elaborate biological networks.
Publications
2014 |
|||
Claudia Stötzel | Numerical and Discrete Modeling of Reproductive Endocrinological Networks | Doctoral thesis, Freie Universität Berlin, Peter Deuflhard (Advisor), 2014 |
PDF
BibTeX |
2013 |
|||
Thomas Dierkes, Susanna Röblitz, Moritz Wade, Peter Deuflhard | Parameter identification in large kinetic networks with BioPARKIN | CoRR - Computing Research Repository - arXiv.org, Vol.abs/1303.4928, 2013 |
PDF
BibTeX |
2012 |
|||
H. Marike T. Boer, Claudia Stötzel, Susanna Röblitz, Henri Woelders | A differential equation model to investigate the dynamics of the bovine estrous cycle | Advances in Systems Biology, pp. 597-606, 2012 |
BibTeX
DOI |
H. Marike T. Boer, Mochamad Apri, Jaap Molenaar, Claudia Stötzel, Roel F. Veerkamp, Henri Woelders | Candidate mechanisms underlying atypical progesterone profiles as deduced from parameter perturbations in a mathematical model of the bovine estrous cycle | Journal of Dairy Science, 95(7), pp. 3837-3851, 2012 |
BibTeX
DOI |
2011 |
|||
Susanna Röblitz, Claudia Stötzel, Peter Deuflhard, Hannah M. Jones, David-Olivier Azulay, Piet van der Graaf, Steven Martin | A mathematical model of the human menstrual cycle for the administration of GnRH analogues | ZIB-Report 11-16 (Appeared in: Journal of Theoretical Biology 321 (2013) pp. 8-27) |
PDF
BibTeX URN |
H. Marike T. Boer, Claudia Stötzel, Susanna Röblitz, Peter Deuflhard, Roel F. Veerkamp, Henri Woelders | A simple mathematical model of the bovine estrous cycle | Journal of Theoretical Biology, 278(1), pp. 20-31, 2011 (preprint available as ZIB-Report 10-06) |
PDF (ZIB-Report)
BibTeX DOI |
Claudia Stötzel, Julia Plöntzke, Susanna Röblitz | Advances in modelling of the bovine estrous cycle: Administration of PGF2alpha | ZIB-Report 11-17 (Appeared in: Theriogenology 78 (2012), pp. 1415-1428) |
PDF
BibTeX URN |
H. Marike T. Boer, Susanna Röblitz, Claudia Stötzel, Roel F. Veerkamp, Bas Kemp, Henri Woelders | Mechanisms regulating follicle wave patterns in the bovine estrous cycle investigated with a mathematical model | Journal of Dairy Science, 94(12), pp. 5987-6000, 2011 |
BibTeX
DOI |