Modern therapies are becoming increasingly complex and tailored to the individual patient.

They are based on quantitative understanding of physiological processes and rapidly growing diagnostic imaging and -omics data. Accordingly, we aim at management of mass data and algorithms for their analysis on HPC systems. We develop innovative diagnostic tools, and models and algorithms for patient-specific treatment simulation and optimization that exploit all available data to improve individualized therapies. Furthermore, we aim at providing these algorithms in form of clinically deployable decision support and workflow optimization systems.

Current Projects

3D Reconstruction from 2D X-ray Images
Adaptive Cardiac Simulation
Analysis and quantification of morphological and structural changes in cartilage
Analysis of Empirical Shape Trajectories
Atlas-based 3D Image Segmentation
BBDC
BIFOLD
Camera Facialis
COMPASS
Computation of Treatments for Infertility Related Endocrinological Diseases
Cranial Shape Analysis
Digital Facial Morphology
Dynamic Multi-modal Knee Joint Registration
Empirical Bayes methods in systems medicine
Enfacement Manipulation in Transmitted Inter-Facial Communication
Fluoromath - Unsupervised Deep Learning to assess Hand Diseases
Geometric Analysis of the Human Spine for image-based diagnosis, biomechanical analysis, and neurosurgery
Graph theoretical approaches to image based position tracking
High-throughput Analysis of Large Medical Data
Identification of Stresses in Heterogeneous Contact Models
Image-based Analysis of in vivo Knee Dynamics
In-vivo forces and musculoskeletal loading conditions in human fracture healing
Individualized Morphological Analysis of the Human Spine
Information-Based Optimization of Surgery Schedules
Integrating data for tooth implants
Kaskade7 Finite Element Toolbox
Manifold-Valued Graph Neural Networks
Markov State Models for Nonequilibrium Molecular Dynamics
MODAL-MedLab
Modelling Inflamed Arthritic Joints
Morning stiffness in patients with rheumatoid arthritis
Morphological Scoring of Disease States
Muskuloskeletal and Functional Analysis
Osteosynthesis Follow-up from 2D X-rays
Reduced Basis Methods in Orthopedic Hip Surgery Planning
Shape-Informed Medical Image Segmentation
Sparse Compressed Sensing Based Classifiers for -Omics Mass-Data
Spline Models for Shape Trajectory Analysis
Temperature-based Estimation of Time of Death in Forensic Medicine
Transfer of Research Prototypes to the Commercial Visualization Systems Amira and Avizo
Treating Osteoarthritis in Knee with Mimicked Interpositional Spacer
Uncertainty Quantification for Bayesian Inverse Problems with Applications to Systems Biology
Visual Support for Positioning Bone-Anchored Hearing Aids

Past Projects

Lossy compression for more efficient communication in high performance computing
Adaptive Algorithms for Optimization of Hip Implant Positioning
BiOPAss
Computational Surgery Planning
Computer-assisted and Model-guided Facial Surgery Planning
Data Processing Algorithms
Dermatology
ENT-Surgery under Consideration of Optimal Nasal Air Flow
Facial Growth
Gait Analysis for Quadruped Animals
HighPerMeshes
Improving Therapy Planning for Hip, Shoulder and Knee Joint Surgery
Individual Cartilage Loading in the Knee Joint
Joint Kinematics
Machine Learning Approaches for Enhanced, Shape Model Based 3D Image Segmentation
Mathematical Modelling of Knee Arthrosis
Mathematical Modelling of the Human Menstrual Cycle
Mesh2NURBS
Optimization Of Surgery Scheduling
Patient-specific Analysis of the Hemodynamics of Cerebral Aneurysms
Quantification of Angiogenesis
Shape Analysis of the Pelvis
Simulated Biomechanics of the Lower Limb
Simulation of Cerebral Circulation
Statistical Analysis of the Shape of the Arthritic Knee
Surgery Planning for Dental Implantology
Trajectory Compression
Transfer of Research Prototypes to the Commercial Visualization Systems Amira and Avizo (until 2012)
Virtual Gastrointestinal Tract
Wear Simulation of Knee Implants
X-ray based Anatomy Reconstruction with Low Radiation Exposure