10.09.2018

Once again, Charité tested analgesic candidates developed by using computer-based simulation methods of the Computational Molecular Design working group at ZIB (our concept has been described in 2017 in the journal Science). The two new substances showed  the predicted effects in the experiments.  ZIB anticipated a pH-dependent effect on pain suppression. The results have now been published as a Scientific Report on nature.comThe pH dependence of the pain-relief drug is important for clinical use, since inflamed tissue, in contrast to healthy tissue is acidic, thus has a lower pH-value. In this way, the researchers are one step closer to the goal of designing locally effective painkillers without the central side effects. This goal is also highlighted in a related Charité press release.