Premature ossified cranial sutures of infants (craniosynostis) may lead to skull deformities in the growth process. Helmet therapies, so-called head orthosis, help to improve the patients' appearance and prevent or reduce functional impairment. The goal of this project is to investigate methods for statistical evaluation of the cranial growth for patients undergoing helmet therapies. New measures enable us to quantify volumetric change as well as local shape changes in order to optimize the outcome of such therapies.