AA1-19 Drug Candidates as Pareto Optima in Chemical Space
Die Suche nach Wirkstoffkandidaten mit geringen Nebenwirkungen kann als ein multiobjektiven Optimierungsproblem (MOOP) im chemischen Raum interpretiert werden. Mittels...
This project aims at the creation of a MATH+ success story around the mathematics of drug design. It proposes a new drug design strategy for G-protein coupled receptors...
Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design
Scientific Reports, 13(607), 2023
Arne Thies, Vikram Sunkara, Sourav Ray, Hanna Wulkow, M. Özgür Celik, Fatih Yergöz, Christof Schütte, Christoph Stein, Marcus Weber, Stefanie WinkelmannBibTeX DOI
A discontinuous Galerkin method for approximating the stationary distribution of stochastic fluid-fluid processes
Methodology and Computing in Applied Probability, 2022
Vikram Sunkara, Angus Lewis, Giang T. Nguyen, Malgorzata M. O'Reilly, Nigel Bean
BibTeX DOI
On the Sufficient Condition for Solving the Gap-Filling Problem Using Deep Convolutional Neural Networks
IEEE Transactions on Neural Networks and Learning Systems, 33(11), pp. 6194-6205, 2022
Felix Peppert, Max von Kleist, Christof Schütte, Vikram SunkaraBibTeX DOI
PIPELINE FOR SINGLE CELL SEQUENCING OF HUMAN CHONDROCYTE PELLET CULTURES TO DELINEATE IL-1β MODULATED CHANGES IN CELL HETEROGENEITY
Osteoarthritis and Cartilage, 30(Supplement 1), p. S90, 2022
Annemarie Lang, Antja Vester, M. Ferreira-Gomes, G.M. Guerra, Fredrich R. Heinrich, C.C. Götzke, Sebastian Kurmies, Vikram Sunkara, Pawel Durek, Joel D. Boerckel, Mir-Farzin Mashreghi
BibTeX DOI
Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint
Osteoarthritis and Cartilage, 29(6), pp. 905-914, 2021
Vikram Sunkara, Gitta A. Heinz, Frederik F. Heinrich, Pawel Durek, Ali Mobasheri, Mir-Farzin Mashreghi, Annemarie Lang
BibTeX DOI
Inferring gene regulatory networks from single-cell RNA-seq temporal snapshot data requires higher-order moments
Patterns, 2(9), 2021 (preprint available as ZIB-Report 20-25)
Alexia N. Raharinirina, Felix Peppert, Max von Kleist, Christof Schütte, Vikram SunkaraPDF (ZIB-Report) BibTeX DOI
Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint
bioarxiv (Accepted in Osteoarthr. Cartil.), 2020
Vikram Sunkara, Gitta A. Heinz, Frederik F. Heinrich, Pawel Durek, Ali Mobasheri, Mir-Farzin Mashreghi, Annemarie Lang
BibTeX DOI
HIF-stabilization prevents delayed fracture healing
bioarxiv, 2020 (under review)
Annemarie Lang, Sarah Helfmeier, Jonathan Stefanowski, Aditi Kuppe, Vikram Sunkara, Moritz Pfeiffenberger, Angelique Wolter, Alexandra Damerau, Shabnam Hemmati-Sadeghi, Jochen Ringe, Rainer Haag, Anja E. Hauser, Max Löhning, Carsten Perka, Georg Duda, Paula Hoff, Katharina Schmidt-Bleek, Timo Gaber, Frank Buttgereit
BibTeX DOI
How to calculate pH-dependent binding rates for receptor-ligand systems based on thermodynamic simulations with different binding motifs
Molecular Simulation, 46(18), pp. 1443-1452, 2020 (preprint available as ZIB-Report 20-18)
Sourav Ray, Vikram Sunkara, Christof Schütte, Marcus WeberPDF (ZIB-Report) BibTeX DOI
Single molecule mu-opioid receptor membrane-dynamics reveal agonist-specific dimer formation with super-resolved precision
Nature Chemical Biology, Vol.16, pp. 946-954, 2020
Jan Möller, Ali Isbilir, Titiwat Sungkaworn, Brenda Osberg, Christos Karathanasis, Vikram Sunkara, Eugene O Grushevsky, Andreas Bock, Paolo Annibale, Mike Heilemann, Christof Schütte, Martin J. Lohse
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The relative contributions of infectious and mitotic spread to HTLV-1 persistence
PLOS Computational Biology, 2020
Daniel J. Laydon, Vikram Sunkara, Lies Boelen, Charles R. M. Bangham, Becca Asquith
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Algebraic Expressions of Conditional Expectations in Gene Regulatory Networks
Journal of Mathematical Biology, pp. 1779-1829, 2019
Vikram SunkaraPDF BibTeX URN DOI
Discerning the spatio-temporal disease patterns of surgically induced OA mouse models
PLOS One, 14(4), 2019
Tobias Haase, Vikram Sunkara, Benjamin Kohl, Carola Meier, Patricia Bußmann, Jessica Becker, Michal Jagielski, Max von Kleist, Wolfgang Ertel
BibTeX DOI
Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis
Osteoarthritis and Cartilage, 2019
Julia Temp, Dominika Labuz, Roger Negrete, Vikram Sunkara, Halina Machelska
BibTeX DOI
SLCV – A Supervised Learning - Computer Vision combined strategy for automated muscle fibre detection in cross sectional images
PeerJ, 2019
Anika Rettig, Tobias Haase, Alexandr Pletnyov, Benjamin Kohl, Wolfgang Ertel, Max von Kleist, Vikram SunkaraPDF BibTeX URN DOI