Media Name: 432.jpg

Contact

Position
Head of Research Group
Room
0115
Phone
+49 30 84185-432
Email

Projects

Projects as Head

Media Name: MathPlusDD.png

Math-Powered Drug Design

This project aims at the creation of a MATH+ success story around the mathematics of drug design. It proposes a new drug design strategy for G-protein coupled receptors...

Math-Powered Drug Design

Publications

2023
Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design Scientific Reports, 13(607), 2023 Arne Thies, Vikram Sunkara, Sourav Ray, Hanna Wulkow, M. Özgür Celik, Fatih Yergöz, Christof Schütte, Christoph Stein, Marcus Weber, Stefanie Winkelmann BibTeX
DOI
Sunkara, Dr. Vikram
On the Activation Space of ReLU Equipped Deep Neural Networks Procedia Computer Science, pp. 624-635, Vol.222, 2023 Mustafa Chaukair, Christof Schütte, Vikram Sunkara BibTeX
DOI
Sunkara, Dr. Vikram
2022
A discontinuous Galerkin method for approximating the stationary distribution of stochastic fluid-fluid processes Methodology and Computing in Applied Probability, 2022 Vikram Sunkara, Angus Lewis, Giang T. Nguyen, Malgorzata M. O'Reilly, Nigel Bean BibTeX
DOI
Sunkara, Dr. Vikram
Chimeric U-Net–Modifying the standard U-Net towards Explainability bioRxiv, 2022 (under review) Kenrick Schulze, Felix Peppert, Christof Schütte, Vikram Sunkara BibTeX
DOI
Sunkara, Dr. Vikram
On the Sufficient Condition for Solving the Gap-Filling Problem Using Deep Convolutional Neural Networks IEEE Transactions on Neural Networks and Learning Systems, 33(11), pp. 6194-6205, 2022 Felix Peppert, Max von Kleist, Christof Schütte, Vikram Sunkara BibTeX
DOI
Sunkara, Dr. Vikram
PIPELINE FOR SINGLE CELL SEQUENCING OF HUMAN CHONDROCYTE PELLET CULTURES TO DELINEATE IL-1β MODULATED CHANGES IN CELL HETEROGENEITY Osteoarthritis and Cartilage, 30(Supplement 1), p. S90, 2022 Annemarie Lang, Antja Vester, M. Ferreira-Gomes, G.M. Guerra, Fredrich R. Heinrich, C.C. Götzke, Sebastian Kurmies, Vikram Sunkara, Pawel Durek, Joel D. Boerckel, Mir-Farzin Mashreghi BibTeX
DOI
Sunkara, Dr. Vikram
Understanding the Romanization Spreading on Historical Interregional Networks in Northern Tunisia Applied Network Science, Vol.7, 2022 (preprint available as ZIB-Report 22-10) Margarita Kostré, Vikram Sunkara, Christof Schütte, Natasa Djurdjevac Conrad PDF (ZIB-Report)
BibTeX
DOI
Sunkara, Dr. Vikram
Volumetric macromolecule identification in cryo-electron tomograms using capsule networks BMC Bioinformatics, 23(360), 2022 Noushin Hajarolasvadi, Vikram Sunkara, Sagar Khavnekar, Florian Beck, Robert Brandt, Daniel Baum BibTeX
DOI
Sunkara, Dr. Vikram
2021
Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint Osteoarthritis and Cartilage, 29(6), pp. 905-914, 2021 Vikram Sunkara, Gitta A. Heinz, Frederik F. Heinrich, Pawel Durek, Ali Mobasheri, Mir-Farzin Mashreghi, Annemarie Lang BibTeX
DOI
Sunkara, Dr. Vikram
Data-driven modelling of nonlinear dynamics by barycentric coordinates and memory J. Stat. Phys., 2021 (under review) Niklas Wulkow, Péter Koltai, Vikram Sunkara, Christof Schütte BibTeX
arXiv
Sunkara, Dr. Vikram
Inference of historical influence networks International Conference on Complex Networks & Their Applications Proceedings, pp. 110-113, 2021 Margarita Kostre, Vikram Sunkara, Natasa Djurdjevac Conrad BibTeX
DOI
Sunkara, Dr. Vikram
Inferring cultural and social processes based on patterns of statistical relationships between Synodal texts 2021 (in progress) Ralph Birk, N. Alexia Raharinirina, Konstantin Fackeldey, Tonio Sebastian Richter, Marcus Weber BibTeX
Sunkara, Dr. Vikram
Inferring gene regulatory networks from single-cell RNA-seq temporal snapshot data requires higher-order moments Patterns, 2(9), 2021 (preprint available as ZIB-Report 20-25) Alexia N. Raharinirina, Felix Peppert, Max von Kleist, Christof Schütte, Vikram Sunkara PDF (ZIB-Report)
BibTeX
DOI
Sunkara, Dr. Vikram
Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design ZIB-Report 21-19 Sourav Ray, Arne Thies, Vikram Sunkara, Hanna Wulkow, Özgür Celik, Fatih Yergöz, Christof Schütte, Christoph Stein, Marcus Weber, Stefanie Winkelmann PDF
BibTeX
URN
Sunkara, Dr. Vikram
2020
Combining segmental bulk- and single-cell RNA-sequencing to define the chondrocyte gene expression signature in the murine knee joint bioarxiv (Accepted in Osteoarthr. Cartil.), 2020 Vikram Sunkara, Gitta A. Heinz, Frederik F. Heinrich, Pawel Durek, Ali Mobasheri, Mir-Farzin Mashreghi, Annemarie Lang BibTeX
DOI
Sunkara, Dr. Vikram
HIF-stabilization prevents delayed fracture healing bioarxiv, 2020 (under review) Annemarie Lang, Sarah Helfmeier, Jonathan Stefanowski, Aditi Kuppe, Vikram Sunkara, Moritz Pfeiffenberger, Angelique Wolter, Alexandra Damerau, Shabnam Hemmati-Sadeghi, Jochen Ringe, Rainer Haag, Anja E. Hauser, Max Löhning, Carsten Perka, Georg Duda, Paula Hoff, Katharina Schmidt-Bleek, Timo Gaber, Frank Buttgereit BibTeX
DOI
Sunkara, Dr. Vikram
How to calculate pH-dependent binding rates for receptor-ligand systems based on thermodynamic simulations with different binding motifs Molecular Simulation, 46(18), pp. 1443-1452, 2020 (preprint available as ZIB-Report 20-18) Sourav Ray, Vikram Sunkara, Christof Schütte, Marcus Weber PDF (ZIB-Report)
BibTeX
DOI
Sunkara, Dr. Vikram
Single molecule mu-opioid receptor membrane-dynamics reveal agonist-specific dimer formation with super-resolved precision Nature Chemical Biology, Vol.16, pp. 946-954, 2020 Jan Möller, Ali Isbilir, Titiwat Sungkaworn, Brenda Osberg, Christos Karathanasis, Vikram Sunkara, Eugene O Grushevsky, Andreas Bock, Paolo Annibale, Mike Heilemann, Christof Schütte, Martin J. Lohse BibTeX
DOI
Sunkara, Dr. Vikram
The relative contributions of infectious and mitotic spread to HTLV-1 persistence PLOS Computational Biology, 2020 Daniel J. Laydon, Vikram Sunkara, Lies Boelen, Charles R. M. Bangham, Becca Asquith BibTeX
DOI
Sunkara, Dr. Vikram
2019
Algebraic Expressions of Conditional Expectations in Gene Regulatory Networks Journal of Mathematical Biology, pp. 1779-1829, 2019 Vikram Sunkara PDF
BibTeX
URN
DOI
Sunkara, Dr. Vikram
Discerning the spatio-temporal disease patterns of surgically induced OA mouse models PLOS One, 14(4), 2019 Tobias Haase, Vikram Sunkara, Benjamin Kohl, Carola Meier, Patricia Bußmann, Jessica Becker, Michal Jagielski, Max von Kleist, Wolfgang Ertel BibTeX
DOI
Sunkara, Dr. Vikram
On the Properties of the Reaction Counts Chemical Master Equation Entropy, 21(6), p. 607, 2019 Vikram Sunkara BibTeX
DOI
Sunkara, Dr. Vikram
Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis Osteoarthritis and Cartilage, 2019 Julia Temp, Dominika Labuz, Roger Negrete, Vikram Sunkara, Halina Machelska BibTeX
DOI
Sunkara, Dr. Vikram
SLCV – A Supervised Learning - Computer Vision combined strategy for automated muscle fibre detection in cross sectional images PeerJ, 2019 Anika Rettig, Tobias Haase, Alexandr Pletnyov, Benjamin Kohl, Wolfgang Ertel, Max von Kleist, Vikram Sunkara PDF
BibTeX
URN
DOI
Sunkara, Dr. Vikram